Of course, it's Tellah from Final Fantasy IV (or at least the original English translation of it, Square nixed it in the PSX version).

MentalEpsy, you are correct! ...really? They changed it in the PSX version? But it was such a cool line...

I know it's only been 4 hours but I didn't see much activity so I thought I'd jump in with one. This one might be kinda hard.
"Somebody should hit you in the face with a brick".

Very fun game :) but i found it was rather short for such a game. Maybe they did add the extra missions but i doubt it :p
Anyway there's indeed a guy inthere quoting almost the same thing.
There's tons of games and thousands of quotes so i guess once in a while we'll have this problem :)

Unfortunately, I don't know rayven998's one, but I'd like to have it rolling again, so here's one more...
"Arrivederci il mio amigo!"
I know, it SEEMS a bit generic, but I know of only one place where such a simple farewell is made into such a distorted anomaly ;-).

Grim Fandango?

Which one did you intend it for? (Yes, that's the curse of having multiple ones running along...)
If mine, then nope.

I did mean yours so evidently its not my go. I'd suggest we only have one quote going at a time or it'll get confusing as hell

Yeah, but having one quote can lead to unfcomfortably long pauses (no one knows the solution, and everyone waits, thinking maybe others will know), meaning the thread gets buried. This is why Fenixp suggested the current method in post #21.
I think quotes should automatically "expire" after, say, 8 hours, that way there'd be no misunderstandings as to who you answered to. Also, the poster of the then-expired quote should announce what the right solution was when he/she logs on the next time.

Well fair enough then, suppose yours has expired now so I'll post another
"I think therefore I am. I think"

That's Nordom, the Backwards Modron of Planescape: Torment speaking. Did you use this line in the other thread?
"I killed twelve dumbass scientists and not one of 'em fought back. This sucks."

Half Life 1. I think a random soldier said it.

Correct! Your turn.

I'll go with this:
"Stop poking me!"

Warcraft Orcs?