From my own experience: Yes for most games, with certain reservations. Like Witcher 3 is a game I haven't installed for several reformat of my harddrive. But yeah, easier to just say to try each one.
Though, while the game itself might just re-create the necessary register info, you
have to at least install the external libraries that usually comes included in the games installer:
https://www.techpowerup.com/download/visual-c-redistributable-runtime-package-all-in-one https://www.techpowerup.com/download/directx-redistributable-runtime/
These are the bare-minimum. I install those packages every time I reformat and reinstall Windows. There's a wiki out there that can tell if a game needs more. Most don't.
Also, you'd be surprised how "portable" Windows can be but you may need to re-reactivate depending on the version you have. I have often from XP to 10 installed Windows on an external HDD and have it boot up on another computer, say between job and home computer.
Now, more than often, with graphics card, net card, and going from intel to AMD computer and vice versa, is going to complain about lack of drivers, but it usually won't give you the blue screen (due to standardized fallback drivers that Windows comes with). Same thing with the
PE version, you can anticipate the need for a driver and then either slipstream it before hand or just install the drivers on the live system before moving it to the new computer.