bevinator: I do, occasionally. For really old games with very low resolution it can look a lot better in a smaller window than fullscreen. (usually normal2x)
Arkose: Note that you also have the option of running a game in a non-stretched fullscreen mode (fullresolution=0x0). That way you're seeing just the game with black padding taking up the rest of the space. Scalers can still be applied as usual.
Cool, I'll have to try that sometime. I wasn't aware of the 'fullscreen=0x0" option before.