why does no one have a raging b**** for miranda from ME2 like i do?! she is the hottest character created in a videogame!
i may be a little biased though, i'm an ass man. and we all know where bioware put the camera during every miranda conversation.

I didn't like her at first (bluh bluh huge bitch), but i'm warming up to her.
Shame i hate playing male shepard so much though, no tali or miranda romance for me, doubt i'm missing much with jack though

Totally agree about the camera thing, there were several times where I thought 'that is just not subtle at all.' They also made sure to include her breasts in every shot she was in. Hrrm, 'genetically perfect', probably could have done something about the face, although she is largely based off her Father, which would explain the face, if not the breasts and ass.*
*Please note: any comments by Al1 are strictly ironic, satirical or for humorous intent, and should not be interpreted as his actual opinion. Al1 is in no way a shallow mysoginist, nor would he condone the thoughts, words or actions of any such individuals in any way.
Anyway, as for the video game crushes:
Pretty much any female Bioware character after the BG games save Morrigan, Jack and Ashley.
An obscure one: The Andorian chick (whose name I cannot remember, nor can I find it anywhere online) from Star Trek : Starfleet Academy (The PC version) (bit of a cheat this one as it was a live action FMV game).
Most of the babes from The Witcher (I'm not shallow, it's CD Projeckt who are shallow for making them that way!)
Jeanette/Therese from VTMB. (By the way I was too dense to see the reveal about the characters coming.)
Lara Croft: *Sigh* My first love. She just keeps looking better every time I see her.
May add more later, will have to look some others up.
Edit: Cate Archer From NOLF: Thanks go to BrainCandy for reminding me of her.

I'm surprised nobody mentioned Cate Archer from No One Lives Forever. She would top my list. If we wanted to get into console territory, there is Fran from FFXII.

Very much so. I really enjoy characters from older games (especially BG2, as I mentioned elsewhere) 10 pixel tall characters can't do much for me (as well made as they are) so the personality is a big thing.
Hell, the first time I played through BG2 and Yoshimo turns on you, I was pretty damn pissed.
But his acting of Irenicus was just great.
(Oh, and if you even think "great, Orvidos just spoiled BG2 for me" where the hell have you been?)
Editation: Oh, and it isn't so much of a crush, but again from BG2. Simon Havarian. "Coo' loves. . ." cracks me up every time.

Adding to my list; Imoen from both Baldur's Gate games. I could never leave her behind, even though I really know she's pretty much useless.

No way. Give her a bow and elven mail, and she is the most badass ma/th out there!! She is the only reason i could ever take down that Demi-Lich in BG2 for that kickass ring (forget the name). I just had to make her immune to time-stop (I think) with whatever that immunity to Abjuration spell was and use that crafted bow... Man, it has been too long, I can't remember hardly ANY specifics.
Anyway, back on topic:
Mira (if you turn her to the dark side) (KOTOR 2)
Handmaiden )KOTOR 2)
Viconia (Baldur's Gate)
Jeanette (but not Therese) (Vampire: Bloodlines)
Liara (ME)
Morrigan (DA:O)
Leliana (DA:O) (she reminds me of Imoen's picture from BG2, actually)
I know I am forgetting something/someone. It will come to me later...
Also, I am so going to look up WTF I am talking about in BG2 and post an edit. I remember I was so proud of myself for finally killing that Demi-Lich...
EDIT (not that anyone will care, but it does prove Imoen is a bad ass! :P):
I was almost right. The Demi-Lich was named Kangaxx., and the ring was called the ring of Gaxx, I used Spell Immunity: Abjuration to make Imoen immune to imprisonment (not time-stop). Then I just gave her Gesen's Bow, which didn't need ammo and was already magical enough to hit the lich. I just stood her out front and let her 'tank' the spells while she plinked him to death with the bow. See, she can be useful!

I didn't even think of Dragon Age
Leliana was a clear standout for me, a hot bisexual french redhead who's more than a little crazy and mentions caramel pudding in distinctly sexual tones? Yes please

Triss - The Witcher
Annah - Torment Gorgeous, sarcastic and voiced by Sheena Easton!
Poison Ivy Batman: AA
Moira - Fallout 3
Leliana - DAO
Kate - GTA 4
I think my predilectin for redheads is showing
Raven - Arcanum
Natasha - Commandos 2
Lara Croft
Imoen - BG
Alice - American McGee
Faith - Mirror's Edge
Karla Valenti - Indigo Prophecy
Silver Fox - jade Empire
Shaundi - Saint's Row 2 even if she can't fight her way out of a paper bag she is voiced by Eliza Dushku
and my Man Crushes
Garrett - Thief series
Sam Fisher - Splinter Cell

There's a lot of guys here talking about girl crushes, so, as a girl, I'll reveal my guy crushes:
*Warning: I play a lot of console games*
The Prince (Prince of Persia 2008)
Kuja (Final Fantasy IX)
Balthier (Final Fantasy XII)
Cloud, Zack, and Reeve (Final Fantasy VII & its spin-offs)
Ratchet (Ratchet & Clank Series)
Guybrush Threepwood (Monkey Island Series)
Sora (Kingdom Hearts Series)
Zero (Megaman X Series)
Yuri (Shadow Hearts I & II)
Jin Uzuki (Xenosaga Series)
Kairu and Nephi (Black Sigil: Blade of the Exiled)

Oh yeah, and I forgot:
The Witcher had a fair amount of girls, but which was my favorite out of all of them? Well, since I never actually beat the game, but I have seen all the uncensored cards, my favorite would have to be Abigail. NOT her in game render, but the way she looks on the card. If only they were capable of rendering her like that in the game....and I mean with clothes, not nude :P

Okay so I looked at the card, and, uh...

true dat.
also, the boobs of bloodrayne, since they are the only thing moving on her in the cutscenes.

Everyone wants to bang batman...
Zoe from Dreamfall
Mission from KOTOR1 (all blue twilleks btw but her especially)
Rayne... just rayne.... mmmhmmmhmm!
Exile....
Revan (male or female. i would bang like the world is about to end)
April Rayne, Alyx... i find them attractive but wouldn't want to bang them. just to be friends :)
Edit: jesus how could i forget: Jeanette! Jeanette! Jeanette! and Jeanette! again!
that goes for voice actress too.... any character voiced by her whether it is 80 year old vampire nymph or 16 year old psychotic fire bitch ;)

Lilith from Borderlands. :|