Ianis: Personally the moment that annoyed me with my Alchemy-sword build , was in Chapter 3 , the fight in Dethmold's HQ , once you entered it you could not drink a potion anymore even though you were not in a wraith mist this time , just in the central court of Kaedweni HQ of Loc Muine , that was annoying because Geralt had all the time in the world to do it after killing the first wave of soldiers , but a message telling you "you can't meditate at this time " prevented you to do it until you got out of Dethmold's HQ .
Same against the Dragon , i thought i could drink a potion just before the fight , but it wasn't possible , i had to drink it way before , just before going to the war council actually , but since the timer goes on during the chat , you end up with 3 minutes to kill the dragon .. unless you invested in potion duration talents , but i didn't .
I agree about not being able to meditate / drink potions in Dethmold's HQ. However the human opponents are rather easily dispatched (they are slow and they don't leap), unlike the Draug who has a long reach, relatively large area of effect, and has the aid of trebuchet / archer.
Btw for the dragon fight, you can actually meditate right before entering Sile's tower.
Kahunaburger: I'm pretty sure you're supposed to fight the Draug without potions. Fortunately, the Draug fight is (in my experience) the easiest boss fight even without your potions. Really, the loss of potions is a pretty serious blow to any build, not just an alchemy-focused one. All those mist fights gimp your abilities in various ways - for instance, the sword fights are unusually hard for a magic class.
lw2jgog: Depends on your build. So far, I've done two runs -- a Roche-path swordsman/mage combo (to the degree of getting both Heliotrope + Group Finisher, and adrenalin for basically doing anything), and an Iorveth-path almost pure mage (spent six points in training, spent most points in mage, spent two points to get Position to compensate for low hp/damage resistance, then spent another two points in training for more vitality). The latter was *extremely* good at dealing with mobs of soldiers, harpies or necrophages, but with circa 400 hp / less than 70 armor / low damage reduction, highly vulnerable to single tough long-reach opponents in very confined spaces like the Draug boss, or the golem in Loc Muinne.
The second encounter with Letho might be the easiest for a non-swordsman-specialist, because you can keep your distance indefinitely by running in circles around the water; Letho takes the shortest path, even if it's running into Yrdens; and Letho doesn't automatically use his ranged attacks as soon as he can (at least on Normal). He's very nasty up-close, however.
Point is that any pure-path specialist gets hurt badly somewhere. The game's design strongly encourages spending a fair number of points in the Swordsman tree to get the extra vitality and damage reduction, at least, but even a very tough Swordsman specialist will need to be at least somewhat careful against crowds, and going purist and not having Heliotrope is pretty harsh.
True. All builds are damaged by the no-potion boss. However the Alchemists take the heaviest damage since they rely on potions to activate the passive bonuses. On the other hand, the Swordsmen still have their buffs/techniques and the Mages have access to all their spells.
Don't think Swordsman without Heliotrope is that hard. I mean I can buff up my Catalyst and down some potions to become a tank. I didn't even have the group style and I only acquired the group finisher near the end.