CRB99: The provided code is the one I've put no?
;--- Xpadder Profile File ---
DataType=Profile
Version=2011.05.13
[Profile Settings]
[Set Settings]
[Assignments]
Set1Button1Name=Jump
Set1Button1Slots=Space
Set1Button2Name=Character Sheet
Set1Button2Slots=C
Set1Button3Name=Reload\Use
Set1Button3Slots=R,HOLD ZONE 0.10s,E
Set1Button4Name=Inventary
Set1Button4Slots=I
Set1Button5Name=Feed
Set1Button5Slots=F
Set1Button6Name=Attack mode
Set1Button6Slots=Tab
Set1Button7Name=Log
Set1Button7Slots=L
Set1Button8Name=Menu
Set1Button8Slots=Escape
Set1Button9Name=Crouch
Set1Button9Slots=Left Control
Set1Button10Name=FPS\TPS
Set1Button10Slots=Z
Set1DPadUpName=Melee
Set1DPadUpSlots=F1
Set1DPadRightName=Power Right
Set1DPadRightSlots=Mouse Wheel Up
Set1DPadDownName=Gun
Set1DPadDownSlots=F2
Set1DPadLeftName=Power Left
Set1DPadLeftSlots=Mouse Wheel Down
Set1Stick1UpName=Move
Set1Stick1RightName=Move
Set1Stick1DownName=Move
Set1Stick1LeftName=Move
Set1Stick2UpName=Look
Set1Stick2UpSlots=Mouse Move Up
Set1Stick2UpMouseSpeed=62
Set1Stick2RightName=Look
Set1Stick2RightSlots=Mouse Move Right
Set1Stick2RightMouseSpeed=62
Set1Stick2DownName=Look
Set1Stick2DownSlots=Mouse Move Down
Set1Stick2DownMouseSpeed=62
Set1Stick2LeftName=Look
Set1Stick2LeftSlots=Mouse Move Left
Set1Stick2LeftMouseSpeed=62
Set1TriggerLeftName=Power
Set1TriggerLeftSlots=Right Mouse Button (2)
Set1TriggerRightName=Attack
Set1TriggerRightSlots=Left Mouse Button (1)
Set3Stick2UpSlots=Mouse Move Up
Set3Stick2UpMouseSpeed=32
Set3Stick2RightSlots=Mouse Move Right
Set3Stick2RightMouseSpeed=32
Set3Stick2DownSlots=Mouse Move Down
Set3Stick2DownMouseSpeed=32
Set3Stick2LeftSlots=Mouse Move Left
Set3Stick2LeftMouseSpeed=32
Set3TriggerLeftSlots=Right Mouse Button (2)
Set3TriggerRightSlots=Left Mouse Button (1)
CRB99: The autoexec is correct?
joyname "Xbox360 controller"
joyadvanced 1
joyadvaxisx 3
joyadvaxisy 1
joyadvaxisz 0
joyadvaxisr 2
joyadvaxisu 4
joyadvaxisv 0
joyforwardsensitivity -0.60
joysidesensitivity 0.60
joypitchsensitivity 0
joyyawsensitivity 0
joyadvancedupdate
crosshair 1
joyyawthreshold 0.24
joypitchthreshold 0.20
joysidethreshold 0.20
joyforwardthreshold 0.19
Due to patches like True Patch Gold or so, the autoexec.cfg might already exist. If so, just paste it into that. Did you install DS4Windows?